Diazepam is N-demethylated by CYP3A4 and 2C19 for the Lively metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 towards the Lively metabolite temazepam. N-desmethyldiazepam and temazepam are each further more metabolized to oxazepam. Temazepam and oxazepam are largely removed by glucuronidation.acute slim angle glaucoma (problem by whi